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Ornithine (L-Ornithine) is a key amino acid (along with arginine and citrulline) involved in the urea cycle (the process by which humans and other mammals excrete ammonia). Exercise elevates ammonia levels in the blood which, in turn, increases fatigue.

Supplementation with ornithine has been shown to decrease ammonia concentration during prolonged exercise and, as a result, overall fatigue. This leads to the ability to excercise longer and increase energy (ammonia has also been shown to interfere with glycogen (the body's main fuel) production as well). For these reasons, ornithine is often found in anti-fatgue supplements.

Ornithine is not a proteinogenic (protein building) amino acid and is made from other amino acids like Arginine and citrulline.  


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